ICCS Best Practice Guidance - Read-Across

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ICCS Best Practice Guidance Document - Read-Across

This Best Practice Guidance (BPG) document provides insights into using a read-across

approach for both human health and environmental safety. The document aims to increase the use and acceptance of read-across by proposing a structured workflow for safety assessors. The primary goal of this document is to inform hazard and safety assessments for both human health and environment without the need for new animal testing. This BPG explains the key principles and steps involved in read-across based on the analogue and category approach, namely problem formulation, analogue(s) identification and evaluation, suitability assessment and characterization and mitigation of potential uncertainties related to the chosen analogue(s). The importance of documentation and transparency is emphasized, with guidance on reporting decisions, input variables and assumptions.

This guidance is designed for safety assessors. It assumes a baseline understanding of read-across and cosmetic safety assessment, and it follows Next Generation Risk Assessment principles. This BPG was developed through an iterative process involving literature reviews and expert input. The guidance outlined herein is based on current best practices and will be updated as scientific advancements occur.

We want to know what you think!

We are very excited to have published our first in a series of Best Practice Guidance documents for use by the global safety assessment community for substances in cosmetics and personal care products.

Please provide feedback on what you think about this BPG document and its applicability to your safety assessment activities.