ICCS Educational Resources and Training
INTERNATIONAL COLLABORATION ON COSMETICS SAFETY
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ICCS TRAINING
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NAMs 101
Designed for an audience new to NAMs and NGRA frameworks, this tool will be available soon.
NAMs 101
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NGRA Case Studies: Benzophenone-4
Benzophenone-4 case study given by Matthew Dent of Unilever.
Japanese captions are available through closed captioning.
NGRA Case Studies: Benzophenone-4
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Updates on New Approach Methodologies (NAMs) Applied to Human and Environmental Safety Webinar Serie (Portuguese / Spanish)
This webinar serie will cover topics ranging from:
- Next Generation Risk Assessment (NGRA)
- PBPK modeling
- Validation
- (Q)SARs
- Legislative changes in Latin America
Updates on New Approach Methodologies (NAMs) Applied to Human and Environmental Safety Webinar Serie (Portuguese / Spanish)
EXTERNAL TRAINING
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AFSA Master Class in Animal-Free Safety Assessment Collaboration
The Animal-Free Safety Assessment Collaboration has developed a first-of-its-kind “Master Class” in Animal-Free Risk Assessment for cosmetics and cosmetic ingredients.
The course covers the entire risk assessment process in 10 modules (8 are currently available). The course is freely available online and can be taken at your own pace.
AFSA Master Class in Animal-Free Safety Assessment Collaboration
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ASCCT Webinars
The American Society for Cellular and Computational Toxicology (ASCCT) is a scientific society dedicated to the promotion of toxicology testing and research that reduces and replaces the use of animals. This webpage compiles upcoming webinars from ASCCT and its partners.
ASCCT Webinars
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CTPA Online Learning Platform
CTPA has created this e-learning course on 'Safety Assessment for Cosmetic Products'. The course consists of the following seven modules, each delivered by industry experts.
- Overview of the Cosmetic Product Safety Report (CPSR)
- Key toxicological principles in cosmetic safety assessment
- Local toxicity (skin irritation, eye irritation, skin sensitisation and phototoxicity)
- Systemic toxicity (repeated dose toxicity, genotoxicity/mutagenicity/carcinogenicity and reproductive toxicity)
- Packaging, microbiology, stability and cosmetovigilance
- Safety assessment of fragrances and botanical ingredients
- Next Generation Risk Assessment (NGRA) for cosmetic safety
The course is soon going to be updated with the following new modules: 'The CPSR perspective from the enforcement authorities', 'Safety assessment of nanomaterials', 'Principles of environmental safety', 'Environmental hazards and exposure assessment'
The training is an overview of cosmetic safety assessment, it doesn't focus only on NAMs and NGRA
CTPA Online Learning Platform
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IIVS Training
The Practical Methods training program provides a variety of education and training opportunities, from in-person intensive hands-on courses to lectures, panel discussions, webinars, and consultations that are relevant across all sectors and can include a range of non-animal methods.
IIVS Training
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NURA Training
NURA (NAM Use for Regulatory Application) is a free training resource aimed at expanding the use of non-animal methods in regulatory toxicology. The Physicians Committee hosts various training types, from single hour long webinars to extended multi-session webinars on a focused topic, such as AI Use in Regulatory Application, Carcinogenicity, PBPK, etc. NURA is based in the United States but often addresses international regulatory guidelines.
NURA Training
Additional Resources
Journals
- Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients
- Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure
- Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion
- Next generation risk assessment for occupational chemical safety – A real world example with sodium-2-hydroxyethane sulfonate
- Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients
- A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products
- Applying a next generation risk assessment framework for skin sensitisation to inconsistent new approach methodology information
- Case Study on the Use of Integrated Approaches for Testing and Assessment for skin sensitisation: Demonstrating the Next Generation Risk Assessment Framework using Geraniol
- Next generation risk assessment for skin sensitisation: A case study with propyl paraben
- Read-across can increase confidence in the Next Generation Risk Assessment for skin sensitisation: A case study with resorcinol
- Skin sensitisation prediction using read-across, an illustrative next generation risk assessment (NGRA) case study for vanillin
- A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products
- Incorporating integrated testing strategy (ITSv1) defined approach into read-across (RAx) in predicting skin sensitization potency: ITSv1-based RAx
- Use of in vitro ADME methods to identify suitable analogs of homosalate and octisalate for use in a read-across safety assessment
- ADME characterization and PBK model development of 3 highly protein-bound UV filters through topical application
Conference Presentations
- Models Evaluating the direct-Release of Cosmetic Ingredients (MERCI) - presented SETAC Europe 34th Annual Meeting 2024
- Next Generation Risk Assessment for Occupational Chemical Safety – a Real World Example with Sodium-2-hydroxyethane sulfonate - presented at BTS Annual Congress 2024
- Towards NGRA Skin Sensitisation – Case study on diethanolamine (DEA) - presented at the IDEA workshop on New Approach Methodologies (NAMs) – Application of the Reference Chemical Potency List (RCPL)
- Decision making in Next Generation Risk Assessment (NGRA) for Skin Sensitisation: How useful Read-Across Analogue Data can be - presented at SOT 63rd Annual Meeting and ToxExpo 2024