Aquatic Toxicity: Cosmetic Ingredient Applicability of the OECD TG 249: RTgill-W1 Fish Cell Line Acute Toxicity Assay

Objective

Identify most relevant gaps in the available data for chemicals tested against the gill cytotoxicity assay
Generate high-quality OECD TG 249 data for cosmetic ingredients to evaluate strength in predicting acute fish toxicity.
Identify potential chemical-specific limitations of the OECD TG 249 that may be difficult for ensuring robust environmental risk and hazard assessments and obtaining global regulatory acceptance
Externally communicate findings (e.g., publication, conferences) of the work to support scientific confidence in the method and advance regulatory acceptance

Aquatic Toxicity Working Group

Project Lead:

Poster: Exploring the Applicability of the OECD TG 249 Fish Cell Line Acute Toxicity Assay in Environmental Hazard and Risk Assessment of Cosmetic and Personal Care Product Ingredients.

Significant efforts are being made globally to advance the adoption of animal-free safety assessments. However, acute fish toxicity data are currently a component of environmental risk assessments and often a requirement in global chemical regulations. Thus, to minimize animal use while ensuring the environmental safety of chemicals and products, it is necessary to consider alternative methods for assessing acute fish toxicity that will provide robust and regulatory-compliant approaches. One alternative that has shown utility for assessing acute fish toxicity is the OECD 249 RTgill assay, a rainbow trout gill cytotoxicity assay.

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Poster: Exploring the Applicability of the OECD TG 249 Fish Cell Line Acute Toxicity Assay in Environmental Hazard and Risk Assessment of Cosmetic and Personal Care Product Ingredients.