Endocrine Disruptors:  Identification of the Available In Vitro and In Silico Assays and Approaches to Determine Whether a Given Chemical has the Potential to Cause an Adverse Event as a Direct Consequence of an Endocrine Disruptive Mode of Action.

This project aims to provide a comprehensive assessment of the available in silico and in vitro assays to assess the potential of a chemical to act as an Endocrine Disrupters (ED) via the EATS MoAs by:

1. Mapping of ED definition and regulatory status
2. Information mining and WoE assessment of a chemical with available data
3. Data generation to evaluate assay performance

Key questions that will be answered with this project:

• What combination of assays is sufficient to assess the endocrine activity of a chemical?
• What is the performance of individual in silico and in vitro methods?
• Can available assays be useful for underpinning endocrine MoA?
• Can we create an in vitro / in silico framework to assess the endocrine activity of a chemical?