Internal Exposure:  Alternative Approaches to Build a Valid PBPK Model for use in Cosmetic Human Safety Assessment.

Objective

Evaluation of pharmacokinetic (PK) analog and physiologically based pharmacokinetic (PBPK) modeling read across concept; Develop guidance on analog selection; develop chemical specific PBPK model.

Project Details

Internal Exposure Working Group

Project Leads:

  • Corrie Ellison, P&G
  • Karim Najjar, Beiersdorf
  • Nazanin Golbamaki, L'Oréal