Internal Exposure:  Pilot Study to Evaluate a Methodology to Characterize the Kinetics of Serum Protein Binding to Inform Decision Making for Hepatic Clearance IVIVE for PBK Modelling

Project Details

Internal Exposure Working Group

Project Leads:

  • Sandrine Spriggs, Unilever
  • Ans Punt, Unilever


Objectives

The objective of this project is to investigate the feasibility of measuring association / dissociation constants as source of data to inform on the likely effect on metabolism clearance extrapolation from differences in protein binding In Vitro and In Vivo.