Internal Exposure:  Evaluation of Extended Clearance Classification System (ECCS) for Rational In Vitro Testing and Reliable PBK Modeling

Project Details

ADME PBPK Internal Exposure Working Group

Project Leads:

  • Nazanin Golbamaki, L'Oréal
  • Shuichi Sekine, Shiseido
  • Karim Najjar, Beiersdorf


Objectives

The overall objective is to increase the reliability of PBK model simulations for cosmetic ingredients. In particular, this project aims to:  

  • Propose a tiered testing strategy and a decision-making framework
  • Identify and evaluate predictive approaches
  • Conduct case studies using cosmetics ingredients to assess the effectiveness and applicability of the proposed framework
  • Disseminate findings through international guidance documents, publications, etc.