Leading Flavor & Fragrance Manufacturer, MANE Joins The International Collaboration on Cosmetics Safety

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April 1, 2025

NEW YORK--ICCS is pleased to welcome MANE as a new partner, further strengthening the commitment to advancing animal-free safety assessments in the cosmetic and personal care industry. This collaboration highlights MANE’s dedication to innovative, ethical testing methods.

“By joining forces with ICCS, MANE reaffirms its commitment to developing and promoting non-animal safety approaches. Together, alongside our global network of ICCS members, we will continue driving progress toward a future free from animal testing,” said Erin Hill, CEO of ICCS.

“At MANE, the protection of animal welfare and the environment is not just a priority - it is a cornerstone of our identity. This unwavering commitment is reflected in our strict policy of not conducting animal tests on our flavor or fragrance compositions,” said Eric Angelini, Vice President, Global Regulatory Affairs & Product Safety, MANE.

“Furthermore, no animal tests are conducted or commissioned for our manufactured ingredients, except where specifically required by national or regional regulations. Our proactive stance extends beyond compliance. We are determined pioneers in the search for alternative methods, investing in cutting-edge research and collaboration to drive the future of ethical testing,” Angelini continued.

Since 2007, MANE has been a shareholder in ImmunoSearch, a research company dedicated to the development of in vitro toxicological testing. Since 2008, MANE has incorporated alternative methods for skin irritation screening in MANE laboratories, using the EPISKIN® model. In addition, MANE has collaborated, partnered with and invested in R&D companies specializing in non-animal testing methodologies, including QSAR modeling (in silico approaches). MANE was established in 1871 and is a leading innovative fragrance and flavoring company. They are known for their independence and entrepreneurial spirit. Their ethical values are respected throughout the globe.

ICCS was formed in early 2023 with the mission to advance the adoption of animal-free assessments of cosmetics, and their ingredients, for human and environmental safety. The organization is comprised of international members from market leaders in the cosmetic product and ingredient manufacturers sector, notable trade and research associations, and influential animal protection organizations.

ICCS continues to work with all stakeholders across the world to accelerate the transition to global use and acceptance of animal-free safety assessments for human and environmental health.

About ICCS

The International Collaboration on Cosmetics Safety (ICCS) is a global initiative focused on advancing the adoption of animal-free safety assessment approaches for cosmetics, personal care products and their ingredients. ICCS is comprised of 42 international members including cosmetic product manufacturers and their suppliers, industry associations, and animal protection organizations all working together to drive greater global awareness to accelerate widespread use of animal-free assessments through research, education, and regulatory engagement. For more details on ICCS and its members, visit www.iccs-cosmetics.org.

About the MANE Group

A one-hundred percent independent, family-owned group, MANE is number one in France and in the top five worldwide in the flavours and fragrances sector. The MANE Group has 50 R&D centres and 29 production sites around the world and employs more than 8,000 people in 39 countries. The group's family adventure kicked off over 150 years ago, when Victor Mane decided to transform the flowers and plants he grew in the Grasse region into fragrant raw materials. What started out as a small local distillery is now an international company renowned for its innovation and corporate sustainability, with products that combine tradition, expertise, and modernity. Minimising environmental impact has been a priority for MANE since its inception. In 2003, MANE was the first Flavour and Fragrance company to sign the United Nations Global Compact. The group is involved in several climate protection initiatives, including the Science Based Targets Initiative. Its head office is located in Bar-sur-Loup, in the south-east of France. www.mane.com

“By joining forces with ICCS, MANE reaffirms its commitment to developing and promoting non-animal safety approaches. Together, alongside our global network of ICCS members, we will continue driving progress toward a future free from animal testing,” said Erin Hill, CEO of ICCS.

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Consumer Healthcare Products Association Joins the International Collaboration on Cosmetics Safety

October 16, 2025

The International Collaboration on Cosmetics Safety (ICCS) today announced that the Consumer Healthcare Products Association (CHPA) has joined its global network of non-governmental, trade/research organizations, and industry partners dedicated to advancing animal-free safety assessments for cosmetics and personal care products. “We are thrilled to welcome CHPA to ICCS,” said Erin Hill, President and CEO of ICCS. “Their leadership in consumer health and dedication to regulatory science will further strengthen our collective mission to promote innovative, human- and environmentally relevant safety assessment strategies. Especially at a time in the U.S., when the Food and Drug Administration is emphasizing reliable alternatives to animal testing, ICCS and its members are united in driving collaborative, science-led approaches that advance public health protection.” Jay Sirois, PhD, Vice President of Scientific and Regulatory Affairs at CHPA, said: “Joining ICCS reflects our shared commitment to modernizing safety evaluation across product categories. This collaboration will help ensure that scientific innovation and regulatory progress move hand in hand, supporting the ongoing development of safe, effective, and trusted self-care products.” The ICCS–CHPA collaboration comes at a pivotal moment following the FDA’s September 30, 2025, communication in which the Agency explicitly encouraged the development of new, reliable alternatives to animal testing for sunscreens. In response, ICCS is offering its support to help the FDA realize its plans for implementing New Approach Methodologies (NAMs) in sunscreen safety assessments. ICCS aims to help ensure that the FDA’s commitment to modern, animal-free science, already demonstrated in other regulatory areas, is fully realized in the sunscreen space. ICCS’ aligned efforts focus on advancing modern, science-based approaches to safety assessment that incorporate new technologies and internationally recognized best practices. The organization also supports a consistent and transparent regulatory framework that enables the broader application of NAMs across product categories. Through continued collaboration and knowledge sharing among regulators, industry, and NGOs, ICCS works to strengthen public health protection while fostering scientific innovation and regulatory modernization. By strengthening partnerships and advancing modern scientific tools, ICCS and its members are setting the stage for lasting progress in regulatory science and public health protection. About ICCS The International Collaboration on Cosmetics Safety is a global initiative headquartered in New York. It brings together scientists from industry, academia, and non-governmental organizations to promote the adoption and regulatory acceptance of animal-free safety science through education, research, and collaboration. Visit www.iccs-cosmetics.org About CHPA The Consumer Healthcare Products Association (CHPA), founded in 1881, is the national trade association representing the leading manufacturers and marketers of consumer healthcare products, including over-the-counter (OTC) medicines, dietary supplements, and OTC medical devices. CHPA is committed to empowering self-care by ensuring that Americans have access to products they can count on to be reliable, affordable, and convenient, while also delivering new and better ways to get and stay healthy. Visit www.chpa.org

ICCS Debuts Best Practice Guidance Series Focus on Skin Sensitization Without Animal Testing

July 21, 2025

The International Collaboration on Cosmetics Safety (ICCS) announces its first-ever Best Practice Guidance (BPG): “Skin Sensitization Assessment: Using New Approach Methods for Substances in Cosmetics and Personal Care Products.” This document marks the inaugural publication in a new series of ICCS Best Practice Guidance documents, developed to support the global transition to animal-free safety science. ICCS was invited to present the BPG at the Integrated Strategies for Safety Assessment of Cosmetics Joint Regulators-Industry Workshop hosted by the International Cooperation on Cosmetics Regulation (ICCR) on July 11, where regulators from more than 12 countries convened to advance non-animal methodologies. “This guidance reflects the collective expertise of ICCS members who came together to align on the development of this unique guidance,” said Erin Hill, President & CEO of ICCS. “It’s a key example of our mission to build global capacity and accelerate the uptake of animal-free safety assessments. We greatly appreciate the opportunity to collaborate with the ICCR to hear their input on the workflow in the document.” Grounded in Next Generation Risk Assessment (NGRA) principles, the BPG offers a structured, science-based workflow that includes practical steps from problem formulation, exposure assessment, data evaluation, to transparent decision-making. It is especially suited for safety assessors experienced in traditional methods but new to using NAMs. What Makes the ICCS BPG Unique This BPG builds on existing international frameworks—such as OECD test guidelines and ICCR principles—by integrating them into a cohesive, assessor-friendly workflow. It emphasizes practical use and real-world safety scenarios and is specifically designed for regulatory safety assessments of cosmetics and personal care products. Notably, the guidance provides tools for transparent decision-making, uncertainty characterization, and exposure-based waiving, offering assessors clear and pragmatic support for transitioning to animal-free science. Key Highlights of the BPG: Step-by-step workflow to guide assessors through skin sensitization hazard and safety assessments without new animal tests. Integration of in silico, in chemico, and in vitro methods, including those aligned with OECD Test Guidelines. Designed for regulatory use, especially for assessors transitioning from animal to non-animal approaches. The full guidance is now freely available for download on the ICCS Website . Looking Ahead The Skin Sensitization BPG is the first in a planned suite of ICCS Best Practice Guidance documents. Forthcoming documents planned are: eye and skin irritation, read-across, thresholds of toxicological concern (TTC), physiologically based kinetic (PBK) modeling, exposure-based waiving, and environmental safety endpoints. These guidance documents will continue to support ICCS’ goal of equipping the international community with practical tools for modern, human-relevant, and animal-free safety assessments.

ICCS 2024 Annual Report

June 26, 2025

Explore the ICCS 2024 Annual Report! Dive into a year of progress in fostering regulatory collaboration, promoting harmonization, and strengthening global capacity. See how ICCS and its members contributed to advancing NAMs and NGRA—and helped shape a more modern, animal-free future.